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Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes.

Identifieur interne : 000568 ( an2020/Analysis ); précédent : 000567; suivant : 000569

Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes.

Auteurs : Wei Zhang [République populaire de Chine] ; Rong-Hui Du [République populaire de Chine] ; Bei Li [République populaire de Chine] ; Xiao-Shuang Zheng [République populaire de Chine] ; Xing-Lou Yang [République populaire de Chine] ; Ben Hu [République populaire de Chine] ; Yan-Yi Wang [République populaire de Chine] ; Geng-Fu Xiao [République populaire de Chine] ; Bing Yan [République populaire de Chine] ; Zheng-Li Shi [République populaire de Chine] ; Peng Zhou [République populaire de Chine]

Source :

RBID : pubmed:32065057

Descripteurs français

English descriptors

Abstract

In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. Likewise, patient will be released upon two times of negative detection from oral swabs. However, many coronaviruses can also be transmitted through oral-fecal route by infecting intestines. Whether 2019-nCoV infected patients also carry virus in other organs like intestine need to be tested. We conducted investigation on patients in a local hospital who were infected with this virus. We found the presence of 2019-nCoV in anal swabs and blood as well, and more anal swab positives than oral swab positives in a later stage of infection, suggesting shedding and thereby transmitted through oral-fecal route. We also showed serology test can improve detection positive rate thus should be used in future epidemiology. Our report provides a cautionary warning that 2019-nCoV may be shed through multiple routes.

DOI: 10.1080/22221751.2020.1729071
PubMed: 32065057


Affiliations:


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pubmed:32065057

Le document en format XML

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<div type="abstract" xml:lang="en">In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. Likewise, patient will be released upon two times of negative detection from oral swabs. However, many coronaviruses can also be transmitted through oral-fecal route by infecting intestines. Whether 2019-nCoV infected patients also carry virus in other organs like intestine need to be tested. We conducted investigation on patients in a local hospital who were infected with this virus. We found the presence of 2019-nCoV in anal swabs and blood as well, and more anal swab positives than oral swab positives in a later stage of infection, suggesting shedding and thereby transmitted through oral-fecal route. We also showed serology test can improve detection positive rate thus should be used in future epidemiology. Our report provides a cautionary warning that 2019-nCoV may be shed through multiple routes.</div>
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<name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name>
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<name sortKey="Du, Rong Hui" sort="Du, Rong Hui" uniqKey="Du R" first="Rong-Hui" last="Du">Rong-Hui Du</name>
<name sortKey="Hu, Ben" sort="Hu, Ben" uniqKey="Hu B" first="Ben" last="Hu">Ben Hu</name>
<name sortKey="Li, Bei" sort="Li, Bei" uniqKey="Li B" first="Bei" last="Li">Bei Li</name>
<name sortKey="Shi, Zheng Li" sort="Shi, Zheng Li" uniqKey="Shi Z" first="Zheng-Li" last="Shi">Zheng-Li Shi</name>
<name sortKey="Wang, Yan Yi" sort="Wang, Yan Yi" uniqKey="Wang Y" first="Yan-Yi" last="Wang">Yan-Yi Wang</name>
<name sortKey="Xiao, Geng Fu" sort="Xiao, Geng Fu" uniqKey="Xiao G" first="Geng-Fu" last="Xiao">Geng-Fu Xiao</name>
<name sortKey="Yan, Bing" sort="Yan, Bing" uniqKey="Yan B" first="Bing" last="Yan">Bing Yan</name>
<name sortKey="Yang, Xing Lou" sort="Yang, Xing Lou" uniqKey="Yang X" first="Xing-Lou" last="Yang">Xing-Lou Yang</name>
<name sortKey="Zheng, Xiao Shuang" sort="Zheng, Xiao Shuang" uniqKey="Zheng X" first="Xiao-Shuang" last="Zheng">Xiao-Shuang Zheng</name>
<name sortKey="Zhou, Peng" sort="Zhou, Peng" uniqKey="Zhou P" first="Peng" last="Zhou">Peng Zhou</name>
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   |texte=   Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes.
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